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目的：探讨ｖ－ｓｉｓ、ｃ－ｍｙｃ、ｃ－ｆｏｓ三种癌基因ｍＲＮＡ的协同表达在脑膜瘤中的作用。方法：用原位杂交结合图像分析方法对三种癌基因在脑膜瘤中的ｍＲ－ＮＡ表达状况进行了定量研究。结果：ｖ－ｓｉｓ、ｃ－ｍｙｃ、ｃ－ｆｏｓ在脑膜瘤中的表达率依次为６０．７％、４３．３％和５７．１％，脑膜瘤中ｃ－ｍｙｃ和ｃ－ｆｏｓ的ｍＲＮＡ表达间呈正相关，而ｖ－ｓｉｓ和ｃ－ｍｙｃ的ｍＲＮＡ表达间只在纤维细胞型脑膜瘤（ＦＭ）中呈正相关。结论：这三种癌基因表达增高在脑膜瘤中具有一定作用。ｃ－ｍｙｃ和ｃ－ｆｏｓ的协同表达在脑膜瘤发生发展中具有特殊意义，ｖ－ｓｉｓ和ｃ－ｍｙｃ协同表达在ＦＭ中也有特异性作用，说明各组织分型的脑膜瘤在发生发展中具有一定的遗传异质性。
Objective: To investigate the role of co-expression of three oncogenes v-sis, c-myc and c-fos in meningioma. Methods: In situ hybridization and image analysis were used to quantitatively study the expression of mR-NA in three meningiomas. Results: The expression rates of c-myc and c-fos in meningiomas were 60.7%, 43.3% and 57.1%, respectively. The mRNA expressions of c-myc and c-fos in meningioma There was a positive correlation between v-sis and c-myc mRNA expression only in fibrocystic meningioma (FM). Conclusion: The increased expression of these three oncogenes plays a role in meningioma. The synergistic expression of c-myc and c-fos is of special significance in the development of meningiomas. The co-expression of v-sis and c-myc also has a specific role in FM, indicating that meningioma of each tissue type has Certain genetic heterogeneity.