恶性肿瘤严重威胁人类的生命,对于恶性肿瘤细胞生长演化机制的了解直接影响着临床治疗的原则。肿瘤干细胞(tumor stem cell,TSC)被认为是恶性肿瘤发生、发展、转移和治疗后复发的根本原因。非编码RNA(non-coding RNA,nc RNA)在各种肿瘤干细胞中都起到了重要的调控作用。了解nc RNA在TSC中的调控机制有助于我们进一步了解癌症的发病机理,为新的治疗策略提供思路。 Malignant tumors pose a serious threat to human life. The understanding of the mechanism of malignant tumor cell growth directly affects the principle of clinical treatment. Tumor stem cells (TSCs) are considered as the root cause of malignant tumor recurrence, development, metastasis and post-treatment. Non-coding RNA (ncRNA) plays an important regulatory role in various cancer stem cells. Understanding the regulatory mechanism of nc RNA in TSC will help us to understand more about the pathogenesis of cancer and provide ideas for a new therapeutic strategy.