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①目的观察多烯康对脑血栓病人血清高密度脂蛋白及其亚组分的影响。②方法给３５例脑血栓病人口服多烯康２８ｄ，观察血清高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）及其亚组分（ＨＤＬ２－Ｃ，ＨＤＬ３－Ｃ）改变，并取４０例健康成年人为对照组。③结果治疗前病人血清ＨＤＬ－Ｃ，ＨＤＬ２－Ｃ，ＨＤＬ２－Ｃ／ＨＤＬ３－Ｃ均明显低于对照组。服用多烯康２８ｄ后，ＨＤＬ－Ｃ浓度有所升高，但无统计学意义。ＨＤＬ亚组分ＨＤＬ２－Ｃ浓度和ＨＤＬ２－Ｃ／ＨＤＬ３－Ｃ比值均升高，治疗前后相比均具有显著差异（ｔ＝２．５２，Ｐ＜０．０１；ｔ＝１．８５，Ｐ＜０．０５）。３５例病人服药前后未见肝功能改变，也无恶心呕吐症状出现。④结论多烯康可提高ＨＤＬ，特别对ＨＤＬ２－Ｃ的作用较明显，本药为一种较有前途的防治缺血性脑血管病的药物。
Objective To observe the effect of doeconazole on serum high density lipoprotein and its sub-components in patients with cerebral thrombosis. Methods Thirty-five patients with cerebral thrombosis were treated with polyeneconazole for 28 days. The changes of serum HDL-C and HDL-C, HDL-C and HDL-C were observed. Forty healthy adults were used as control group. ③ Results Serum HDL-C, HDL2-C and HDL2-C / HDL3-C in patients before treatment were significantly lower than those in the control group. HDL-C concentrations increased after 28 days of treatment with polyene but there was no statistical significance. HDL subgroup of HDL2-C concentration and HDL2-C / HDL3-C ratio were elevated before and after treatment were significantly different (t = 2.52, P <0.01; t = 1.85, P < 0.05). No change of liver function was found in 35 patients before and after treatment, and no symptoms of nausea and vomiting appeared. CONCLUSION Docetaxel can increase HDL, especially for HDL2-C. This medicine is a more promising drug for the prevention and treatment of ischemic cerebrovascular disease.