问题:普鲁卡因青霉素是否会降低矿胺尖药物的疗效?答:首先须谈一谈关于磺胺类药物抑菌作用的概念。1940年 Woods 氏从多种细菌和动物组织里提出一种氨基芳香酸,有阻碍磺类药物抑菌的作用;以后他又发现对氨苯甲酸的阻碍作用最强。同年 Fildes 氏认为对氨苯甲酸参与细菌重要的新陈代谢过程,它能够和细菌体内的一种酶相结合,而促进细菌的新陈代谢、生长和繁殖。磺胺类药物的化学构造式,与对氨苯甲酸颇为相似(见下图),所以在一定的浓度时,也可以和细菌体内的酶相结合。一旦磺胺类药物和细菌的酶结合之后,酶的固有机能即受到阻碍,则细菌的代谢、生长和繁殖都遭受抑制。对氨苯甲酸和细菌体内酶的亲合力,远此磺胺强大。所以无论在体内或培养基中,少量的对氨苯甲酸,就可以对抗较高浓度的磺胺。兹将 Woods 就五种磺胺类药物,分析它们对 Question: Will procaine penicillin reduce the efficacy of mineral amine tip drugs? A: First, we must talk about the concept of antibacterial effect of sulfa drugs. In 1940, Woods proposed a kind of aminoaromatic acid from many kinds of bacteria and animal tissues, which hindered the bacteriostasis of sulfonamides. Later, he found the strongest inhibitory effect on aminobenzoic acid. In the same year, Fildes believes that aminobenzoic acid is involved in the important metabolic process of bacteria. It can combine with an enzyme in bacteria to promote the metabolism, growth and reproduction of bacteria. The chemical structure of sulfa drugs, and quite similar to the amino acid (see below), so at a certain concentration, it can also be combined with bacteria in the enzyme. Once the binding of sulfa drugs and bacteria ’s enzymes is hindered by the innate function of enzymes, bacterial metabolism, growth and reproduction are inhibited. Amino benzoic acid and bacteria in the enzyme affinity, far stronger than sulfa. So whether in the body or medium, a small amount of p-aminobenzoic acid, you can fight a higher concentration of sulfonamides. Will Woods on five sulfa drugs, analyze them