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我国乳腺癌发病率日益升高,内分泌治疗是乳腺癌全身治疗的主要方法之一,疗效好,不良反应少,符合保证疗效和提高生活质量的现代乳腺癌治疗原则。随着乳腺癌内分泌治疗的发展,已经拥有多种内分泌治疗的选择,如卵巢去势、药物去势、三苯氧胺、孕激素、芳香化酶抑制剂、氟维司群等。特别是近年来第三代芳香化酶抑制剂的研制成功使得内分泌治疗日益成为激素受体阳性乳腺癌患者的重要治疗选择。本文就乳腺癌辅助内分泌治疗临床研究进展作一综述。
Increasing incidence of breast cancer in our country, endocrine therapy is one of the main methods of systemic treatment of breast cancer, good efficacy, fewer adverse reactions, in line with the guarantee of efficacy and improve the quality of life of modern breast cancer treatment principles. With the development of breast cancer endocrine therapy, already has a variety of endocrine therapy options, such as ovariectomy, drug castration, tamoxifen, progesterone, aromatase inhibitors, fulvestrant and so on. In particular, the successful development of third-generation aromatase inhibitors in recent years has made endocrine therapy an increasingly important treatment option for patients with hormone receptor-positive breast cancer. This review summarizes the clinical progress of adjuvant endocrine therapy for breast cancer.