论文部分内容阅读
目的调查福建省福州市职员非酒精性脂肪肝患病情况及其相关影响因素。方法对参加健康体检的既往无饮酒史或折合乙醇摄入量<40 g/周的3 884名职员进行调查。内容包括问卷咨询,体格检查、75 g葡萄糖耐量试验、血脂检测、以及肝脏实时超声检查。结果调整年龄性别后,非酒精性脂肪肝总患病率为27.45%,并随年龄增长而增加;男性年龄标化患病率为35.70%,高于女性的17.47%,差异有统计学意义(P<0.05);非酒精性脂肪肝者中肥胖、血脂异常、血压增高、高尿酸血症、低HDL-C血症、高LDL-C血症及血糖异常的患病率均高于非脂肪肝组,差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示,性别、年龄、高甘油三酯血症、肥胖(≥25 kg/m2)、低HDL-C血症、高尿酸血症、高血糖等7项指标与非酒精性脂肪肝密切相关。结论福州市职员中非酒精性脂肪肝患病率较高,肥胖及其相关的多元代谢紊乱与脂肪肝的关系密切,应对相关危险因素进行干预。
Objective To investigate the prevalence of non-alcoholic fatty liver disease among staff in Fuzhou, Fujian Province and its related influencing factors. Methods A total of 3 884 staff members who participated in a healthy physical examination without a previous history of alcohol consumption or equivalent to an ethanol intake of <40 g / week were investigated. Topics include questionnaire consultation, physical examination, 75 g glucose tolerance test, lipids test, and real-time liver ultrasound examination. Results After adjusting for age and sex, the total prevalence of non-alcoholic fatty liver was 27.45% and increased with age. The age-standardized prevalence of men was 35.70%, which was higher than that of women (17.47%), the difference was statistically significant ( P <0.05). The prevalence of obesity, dyslipidemia, elevated blood pressure, hyperuricemia, low HDL-C, high LDL-C and abnormal glucose in non-alcoholic fatty liver were higher than those in non-fatty (P <0.05). Multivariate logistic regression analysis showed that gender, age, hypertriglyceridemia, obesity (≥25 kg / m2), low HDL-C, high Hyperuricemia, hyperglycemia and other 7 indicators are closely related to non-alcoholic fatty liver. Conclusion The prevalence of non-alcoholic fatty liver in Fuzhou staff is high. The obesity and its related multi-metabolic disorder are closely related to fatty liver, and relevant risk factors should be intervened.