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目的探讨染色体9p21上rs1333049基因多态性在新疆维吾尔族(维族)和汉族心肌梗死患者中的分布特征。方法 227例心肌梗死患者(梗死组)(维族115例,汉族112例)和192例冠状动脉造影正常者为对照组(维族92例,汉族100例),应用TaqMan单核苷酸多态性基因分型方法进行基因分型,比较维、汉族梗死组和对照组rs1333049基因型频率和等位基因频率的分布情况。结果维、汉族梗死组rs1333049位点基因型分布频率与对照组比较差异有统计学意义(P<0.05);维族梗死组等位基因分布频率与对照组比较差异有统计学意义(P<0.05),汉族梗死组等位基因分布频率与对照组比较差异无统计学意义(P>0.05);维、汉族梗死组rs1333049位点CC与CG基因型分布频率高于对照组(P<0.05);梗死组维族CC与CG基因型分布频率高于汉族(P<0.05),维族C与G等位基因与汉族比较差异有统计学意义(P<0.05);Logistic回归分析显示,rs1333049的CC表型是新疆维、汉族心肌梗死的独立危险因素。结论染色体9p21的rs1333049位点CC与CG基因型为维族心肌梗死的易感相关危险基因型;C等位基因为维族心肌梗死患者患病的危险等位基因。
Objective To investigate the distribution of rs1333049 polymorphism at chromosome 9p21 in Xinjiang Uygur and Han patients with myocardial infarction. Methods 227 patients with myocardial infarction (infarction group) (Uygur 115 cases, Han 112 cases) and 192 cases of normal coronary angiography (control group Uygur 92 cases, Han 100 cases), the application of TaqMan single nucleotide polymorphism Genotyping by genotyping method to compare the distribution of rs1333049 genotype frequency and allele frequency in Victoria and Han nationality infarction group and control group. Results There was significant difference in genotype frequencies of rs1333049 locus between the two groups (P <0.05). The frequency of allele distribution in Uygur infarction group was significantly higher than that in control group (P <0.05) (P> 0.05). The frequencies of CC and CG genotypes in rs1333049 locus in the Han and the Han nationality infants were higher than those in the control group (P <0.05) The frequencies of CC and CG genotypes in Uighur group were higher than those in Han (P <0.05), but Uighur C and G alleles were significantly different from Han (P <0.05). Logistic regression analysis showed that the CC phenotype of rs1333049 was Independent risk factors for myocardial infarction in Xinjiang and Han nationalities. Conclusion CC and CG genotypes of rs1333049 locus on chromosome 9p21 are risk-related risk genotypes for Uyghur myocardial infarction. C allele is a risk allele for Uyghur myocardial infarction.