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目的总结Vogt-K oyanagi -Harada(V K H )综合征患者的神经系统损害表现，探讨有诊断价值的辅助检查方法。方法对13 例患者的临床资料、脑脊液、影像学和电生理检查结果进行回顾性分析。结果11 例患者出现头痛，其中2 例为首发症状；10 例脑脊液检查结果全部异常（100%）；除常规检查外，5 例行病毒系列检查中1 例EBV-Ig M 阳性；8 例寡克隆区带（OB）检查5 例阳性；5 例髓鞘碱性蛋白(M B P )检查，1 例增高；9 例免疫球蛋白(Ig G )检查，4例增高；IgG24h合成率升高1例头部MRI 示视神经异常信号；1例视觉诱发电位潜伏期延长。结论头痛为本病常见症状，但缺乏特异性；脑脊液、影像学检查尤其是免疫学和病毒学指标以及诱发电位检查是主要的诊断依据。
Objective To summarize the neurological deficits in patients with Vogt-Koyanagi-Harada syndrome (VKH) syndrome and to explore the diagnostic value of the auxiliary examination. Methods The clinical data, cerebrospinal fluid, imaging and electrophysiological examination results of 13 patients were retrospectively analyzed. Results Headache was found in 11 patients, of whom 2 were the first symptom. All 10 patients had abnormal cerebrospinal fluid (100%). In addition to the routine examination, EBV-Ig M was positive in 5 of the 5 patients, and 8 5 cases were detected by MB, 5 cases were diagnosed as MBP, 1 case was elevated, 9 cases were immunoglobulin (Ig G) test and 4 cases were elevated. The rate of IgG24h synthesis increased by 1 case MRI showed optic nerve abnormal signal; 1 case of visual evoked potential latency. Conclusion Headache is a common symptom of this disease, but it lacks specificity. Cerebrospinal fluid and imaging studies, especially immunological and virological indicators, and evoked potentials are the main diagnostic criteria.