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雪灵芝的急性毒性:小白鼠半致死量(LD_(0));iv20.57g/kg、ip12.58g/kg、sc28g/kg。雪灵芝的长期毒性:选用大鼠和犬两种动物,大鼠有高、中、低三个剂量组,犬只有高低两个剂量及一个对照组。大鼠sc,犬口服给药,连续给药4周。观察指标有肝功(GPT、P_(450))、肾功(BUN)、外周血细胞计数及白细胞分类、体重增长情况以及心、肝、脾、肺、肾、脑、胸、胸腺、肾上腺等组织学镜检,并与对照组比较。雪灵芝的毒性很小,与对照组比较无显著性差异,并对肝脏有保护作用。每天每鼠口服给于雪灵芝0.5g,连续给药7个月,测定肝功(GPT)及组织学镜检,给药组与对照组比较无显著性差别。经组化检查,试验组比对照组糖元颗粒增多且个大,说明雪灵芝有保肝作用。雪灵芝的致畸实验;雪灵芝对小鼠、大鼠配对饲养,连续给药一个月,每只母鼠均怀孕,直至自然分娩,观察子代无畸形,生长发育良好。
Acute toxicity of snow ganoderma lucidum: mice lethal dose (LD_(0)); iv 20.57 g/kg, ip 12.58 g/kg, sc28 g/kg. The long-term toxicity of snow Lingzhi: Rats and dogs were used. Rats had high, medium and low doses. Dogs had only two doses of high and low doses and one control group. Rats were sc dosed orally in dogs for 4 weeks. Observed indicators are liver function (GPT, P_(450)), renal function (BUN), peripheral blood cell count and white blood cell classification, weight gain and heart, liver, spleen, lung, kidney, brain, chest, thymus, adrenal glands and other tissues Microscopic examination, and compared with the control group. The toxicity of Xuelingzhi is very small, there is no significant difference with the control group, and there is a protective effect on the liver. Each day, mice were given 0.5g of Xuelingzhi orally for 7 months, and liver function (GPT) and histological examination were performed. There was no significant difference between the administration group and the control group. After histological examination, the experimental group had more and more glycogen granules than the control group, indicating that snow ganoderma had hepatoprotective effects. The teratogenic experiment of Ganoderma lucidum was carried out. The Ganoderma lucidum was paired and reared on mice and rats for one month. Each mother was pregnant until she gave birth naturally. The offspring were observed without abnormalities, and the growth and development were good.