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目的提高对结核菌蛋白衍化物阴性反应的正确认识,降低活动性肺结核诊断的差异性。方法对51例首诊PPD阴性反应者的临床资料进行回顾性分析。结果 51例首诊PPD阴性反应者初诊为肺炎10例、慢性支气管18例、支气管扩张7例、肺部肿瘤6例、肺脓肿4例、支气管肺囊肿和肺大泡各2例、心脏疾患和肋间神经痛各1例;经3次痰涂片检抗酸杆菌阳性29例,试验性抗结核治疗有效10例,经纤维支气管镜检查和病理检查确诊12例。结论应慎重对待PPD阴性反应者的诊断藉以提高活动性肺结核诊断准确率。
Objective To improve the correct understanding of the negative reaction of TB derivative and to reduce the difference of active TB diagnosis. Methods The clinical data of 51 first responders with PPD negative were retrospectively analyzed. Results Of 51 newly diagnosed PPD negative responders, 10 cases were initially diagnosed as pneumonia, 18 cases were chronic bronchitis, 7 cases were bronchiectasis, 6 cases were pulmonary tumor, 4 cases were pulmonary abscess, 2 cases were bronchopulmonary cyst and bullae, Intercostal neuralgia in 1 case. After three sputum smear positive in 29 cases of acid-fast bacilli, 10 cases of experimental anti-TB treatment effective, 12 cases confirmed by fiberoptic bronchoscopy and pathological examination. Conclusions The diagnosis of PPD negative responders should be treated with caution in order to improve the diagnostic accuracy of active pulmonary tuberculosis.