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目的研究CT灌注参数对肺癌放疗的早期疗效和预后的评估价值。方法 77例接受放疗的肺癌患者,根据后期临床观察和肿瘤造影检测,早期放疗有效(CR+PR)42例记为有效组,放疗无效(SD+PD)35例记为无效组,回顾性分析两组放疗结束后CT灌注参数变化以及预后生存相关指标。结果放疗后有效组CT灌注参数血流量(BF)(49.8±25.8)ml/(min·100 g)、血容量(BV)(3.7±2.0)ml/100 g较无效组(68.7±27.6)ml/(min·100 g)、(5.3±1.4)ml/100 g显著较低,差异具有统计学意义(P<0.05);有效组病情无进展生存期(9.5±4.2)个月、总生存期(14.2±4.5)个月较无效组(6.4±4.0)、(9.8±4.2)个月明显较长,差异具有统计学意义(P<0.05)。结论肺癌放疗有效的CT灌注参数BF、BV下降较为明显,且和患者预后生存期存在紧密相关性,CT灌注参数可作为肺癌放疗疗效和预后评估的重要参考指标。
Objective To study the value of CT perfusion parameters in the early curative effect and prognosis of lung cancer radiotherapy. Methods A total of 77 patients with lung cancer undergoing radiotherapy were enrolled. According to the late clinical observation and tumor angiography, the effective rate of early radiotherapy (CR + PR) was 42 and the ineffective radiotherapy (SD + PD) 35 were retrospectively analyzed The changes of CT perfusion parameters and prognosis-related indicators of the two groups after radiotherapy. Results The CT perfusion parameters of the effective group after radiotherapy were 49.8 ± 25.8 ml / (100 g), 3.7 ± 2.0 ml / 100 g (68.7 ± 27.6) ml / (min · 100 g) and (5.3 ± 1.4) ml / 100 g were significantly lower, the difference was statistically significant (P <0.05); the effective group disease progression free survival (9.5 ± 4.2) months, total survival (14.2 ± 4.5) months was significantly longer than that of the invalid group (6.4 ± 4.0) and (9.8 ± 4.2) months, the difference was statistically significant (P <0.05). Conclusions The CT perfusion parameters BF and BV decreased obviously after radiotherapy of lung cancer, and are closely related to the prognosis of patients. CT perfusion parameters can be used as an important reference index for radiotherapy and prognosis evaluation of lung cancer.