Aims: To determine the impact of adverse publicity on MMR uptake and measles susceptibility, including whether vaccinationis delayed and the role of deprivation. Methods: A population data base for all Scotland containing immunisation records for over one million children (n = 1 079 327) born 1987-2004 was analysed. MMR uptake was determined by birth cohort and deprivation category. “Final”uptake (at approx age 6 years) was predicted by linear regression by birth cohort.Measles susceptibility in 1998 and 2003 was determined by postcode sector and district for cohorts combined to construct nursery and primary school age groups. Results: There is evidence of a slight rise in late uptake, but insufficient to compensate for underlying declines. Late vaccination continues to be associated with deprivation, while the most affluent tend to be vaccinated promptly, or not at all. Predicted figures for“final”MMR1 uptake are over 90%, but under 95%. Measle ssusceptibility has increased significantly in nursery children,with an eight fold rise in the number of districts with greater than 20%susceptibility in this group (from 3 to 25). Conclusions:Increased measles susceptibility in nursery children is concerning, particularly in the most vulnerable areas. These figures are likely to increase in the future, as MMR uptake has not yet returned to the previous higher level. Increased susceptibility levels can also be expected in primary schools in the future, as levels of late uptake are insufficient to compensate.Predicted figures for “final”MMR1 uptake are under the herd immunity threshold and campaigns may be required to increase uptake among future primary school children. Aims: To determine the impact of adverse publicity on MMR uptake and measles susceptibility, including both vaccinationis delayed and the role of deprivation. Methods: A population data base for all Scotland containing immunization records for over one million children (n = 1 079 327) born 1987-2004 was analyzed. MMR uptake was determined by birth cohort and deprivation category. “Final” uptake (at approx. age 6 years) was predicted by linear regression by birth cohort. Measles susceptibility in 1998 and 2003 was determined by postcode sector and district for cohorts combined to construct nursery and primary school age groups. Results: There is evidence of a slight rise in late uptake, but insufficient to compensate for underlying declines. while vaccination continues to be associated with deprivation, while the most affluent tend to be The vaccinated promptly, or not at all. Predicted figures for “final” MMR1 uptake are over 90%, but under 95%. Measle ss susceptibility has increased si gnificantly in nursery children, with an eight fold rise in the number of districts with greater than 20% susceptibility in this group (from 3 to 25). Conclusions: Increased measles susceptibility in nursery children is about, particularly in the most vulnerable areas. These figures are likely to increase in the future, as mMR uptake has not yet returned to the previous higher level. final "MMR1 uptake are under the herd immunity threshold and campaigns may be required to increase uptake among future primary school children.