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目的 通过分析1273例不良孕产史人群的染色体核型, 总结探讨其临床细胞遗传学意义.方法 常规培养外周血淋巴细胞, 制片后G显带, 并对其染色体进行核型分析.结果 1273例患者中共检出异常核型132例, 染色体异常核型检出率为10.37％.结论 染色体核型异常与不良孕产史的发生有一定的关系.对不孕不育、流产、胎停及生育畸形儿的夫妇进行细胞遗传学检查具有重要临床意义, 可以为临床诊断、治疗提供科学依据.“,”Objective:To analyze chromosomal karyotype of the 1273 cases with adverse pregnancy history, explore and summarize the cytogenetic significance. Methods:Blood samples from all patients were collected for routine cytogenetic analysis.G-banding was performed using cultured peripheral blood lymphocytes, and karyotype analysis under microscope was carried out. Results:Among 1273 cases, 132 cases were found with non-chromosomal polymorphic variants, the abnormal rate was 10.37％. Conclusion:Adverse pregnancy history are associated with chromosome abnormality.The couples with histories of such as infertility、abortion、stillbirth and fetal malformation and so on, should analyze the chromosomal karyotype. Cytogenetic analysis can provide aids on the diagnosis and treatment to the couples with adverse pregnancy history.