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采用免疫组织化学碱性磷酸酶标记ＡＢＣ－ＡＰ（ＡＢＣ－ＡＰ）法显示，用图像分析仪进行定量分析，研究了白细胞介素－１（ＩＬ－１）、白细胞介素－６（ＩＬ－６）、肿瘤坏死因子（ＴＮＦ）和γ－干扰素（ＩＦＮ－γ）对外周血单个核细胞白细胞分化抗原ＣＤ１１ｂ表达的调节作用。结果表明，４种细胞因子中有３种对单个核细胞表面ＣＤ１１ｂ抗原的表达有不同程度的上调作用，强度依次为ＩＬ－６＞ＩＬ－１＞ＴＶＦ；ＩＬ－１还有使ＣＤ１１ｂ抗原在细胞膜上的分布呈集中化的趋势。
Immunohistochemical ABC-AP (ABC-AP) method was used to detect the expression of interleukin-1 (IL-1), interleukin-6 ), Tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) on the expression of peripheral blood mononuclear cell differentiation antigen CD11b. The results showed that three of the four cytokines had different up-regulation of the expression of CD11b on the surface of mononuclear cells, with the order of IL-6> IL-1> TVF. IL-1 also induced CD11b antigen in the cell membrane The distribution is concentrated on the trend.