急性毒性实验表明,泻痢王胶囊LD_(50)无法求出,最大耐受量(MTD)为18.8g生药/kg,该剂量超过临床用量的50倍以上,说明泻痢王胶囊是安全的。长期毒性实验表明,以5.4sg/kg和16.2g/kg剂量连续灌胃给药1个月,未见大鼠出现外观、体重增长、血象、肝肾功能及心、肝、脾、肺、肾、肾上腺、胸腺、甲状腺、胃肠等重要组织脏器的毒性变化。 The acute toxicity test showed that the LD_(50) of Xieyuwang Capsule could not be determined, and the maximum tolerated dose (MTD) was 18.8g crude drug/kg. This dose was more than 50 times of the clinical dosage, indicating that Xieyuwang Capsule is safe. Long-term toxicity experiments showed that rats were continuously administered for one month at doses of 5.4 sg/kg and 16.2 g/kg, but no appearance, weight gain, blood picture, liver and kidney function, and heart, liver, spleen, lung, and kidney were observed. Changes in the toxicity of organs such as adrenal, adrenal, thymus, thyroid, and gastrointestinal organs.