雄激素不敏感性综合征是一类与雄激素受体基因突变密切相关的X染色体隐性遗传病。最新研究表明,该疾病除可引起性发育异常外,还与肥胖、胰岛素抵抗、血脂异常等代谢综合征的危险因素相关。因此,关于雄激素不敏感性综合征与代谢综合征之间的关系已日益成为人们关注的焦点。 Androgen insensitivity syndrome is a class of X-linked recessive genetic disease closely related to androgen receptor gene mutation. Recent studies show that the disease in addition to causing sexual dysplasia, but also with obesity, insulin resistance, dyslipidemia and other metabolic syndrome risk factors. Therefore, the relationship between androgen insensitivity syndrome and metabolic syndrome has increasingly become the focus of attention.