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目的:观察复方灯盏花滴丸对缺血-再灌注过程心肌的保护作用。方法:采用结扎左冠状动脉法,与假手术组、缺血-再灌注组、复方丹参滴丸组相对比,研究了复方灯盏花滴丸对大鼠心肌缺血-再灌注过程超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、钙离子(Ca~(2+))含量的影响。结果:复方灯盏花滴丸显著提高了再灌注心肌的SOD、GSH-Pk活力(P<0.01),显著降低了心肌中MDA和Ca~(2+)含量(P<0.05)。结论:复方灯盏花滴丸对心肌缺血-再灌注损伤具有一定的保护作用,该保护作用的机制可能与清除自由基功能和减轻钙超载有关。
Objective: To observe the protective effect of compound Dengzhanhua Dripping Pills on myocardium during ischemia-reperfusion. Methods: The effect of compound Dengzhanhua Dripping Pills on superoxide dismutation during myocardial ischemia-reperfusion in rats was investigated by ligation of left coronary artery and sham operation group, ischemia-reperfusion group and compound Danshen Dripping Pills group. The effect of enzyme (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), and calcium ion (Ca 2+ ) content. RESULTS: Compound Dengzhanhua Dripping Pills significantly increased the activity of SOD and GSH-Pk in reperfusion myocardium (P<0.01), and significantly decreased the contents of MDA and Ca2+ in myocardium (P<0.05). Conclusion: Compound Dengzhanhua Dripping Pill has a certain protective effect on myocardial ischemia-reperfusion injury. The protective mechanism may be related to the clearance of free radicals and the reduction of calcium overload.