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目的:建立一个连续长期遥控监测清醒动物血压的方法并能连接传统血压测定系统。方法:将无线电遥测装置经腹腔植入大鼠腹主动脉,血压信号通过桥装置记录,使用自编软件计算机处理。在非高血压WKY大鼠中建立了连续遥控监测血压方法后,观察一组8只清醒高血压大鼠术后2~17周的每周连续24 h的血压。结果:本实验连续遥控监测清醒动物24 h血压期间重复测得的大鼠每周连续24 h血压经统计学检验无显著性差异;收缩压和舒张压总平均值分别为:170±2和115±1mmHg。结论:成功建立了连续长期重复遥控监测清醒高血压大鼠血压的方法。
OBJECTIVE: To establish a continuous, long-term, remote-controlled method of monitoring blood pressure in conscious animals and to interface with a conventional blood pressure measurement system. Methods: The radio telemetry device was implanted into the abdominal aorta of rats via abdominal cavity. The blood pressure signal was recorded by bridge device and processed by computer software. After continuous remote monitoring of blood pressure was established in non-hypertensive WKY rats, blood pressure was observed at 24 hours per week for 2 to 17 weeks in a group of 8 awake hypertensive rats. Results: In this experiment, the continuous 24-h blood pressure monitoring of conscious animals during repeated measurements of 24-hour weekly blood pressure by the statistical test showed no significant difference; the average systolic and diastolic blood pressure were 170 ± 2 and 115 ± 1mmHg. Conclusion: The method of continuous long-term repeated remote monitoring of blood pressure in conscious hypertensive rats was successfully established.