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目的 探讨系统性红斑狼疮 (SL E)眼底并发症的临床特点。 方法 回顾性分析 2 5例出现眼底并发症的 SL E患者的眼底、眼部其他表现、伴随的全身病变及血抗核抗体 (ANA)、抗双链 DNA(抗ds DNA)、补体 3(C3)、补体 4 (C4 )和血红细胞沉降率 (ESR)。 结果 “典型的”SL E眼底病变 15例 2 5只眼 ,视网膜静脉阻塞 (RVO) 9例 12只眼 ,RVO合并视网膜动脉不全阻塞 1例 2只眼 ,渗出性视网膜脱离 1例 2只眼 ,玻璃体积血合并新生血管性青光眼 1例 1只眼 ,视盘水肿 (除外 RVO所致 ) 3例 6只眼。 9例合并有眼部其他表现 ,2 1例患者伴随有全身症状 ,所有病例血抗核抗体 (ANA)、抗 ds DNA阳性和血 ESR升高 ,19例 C3下降 ,17例 C4 下降。 结论 SL E可产生严重的眼底并发症及合并其他眼部病变 ,对 SL E患者应定期进行眼科检查 ,以便早期发现眼底病变并及时进行治疗。
Objective To investigate the clinical features of fundus complications of systemic lupus erythematosus (SLE). Methods We retrospectively analyzed the fundus, ocular manifestations, systemic pathology, ANA, anti-dsDNA and C3 in 25 SLE patients with retinal complications. ), Complement 4 (C4), and erythrocyte sedimentation rate (ESR). Results The “typical” SL E fundus lesions were observed in 15 eyes (25 eyes), retinal vein occlusion (RVO) in 9 eyes and 12 eyes, RVO complicated with retinal artery insufficiency in 1 patient and 2 eyes, exudative retinal detachment in 1 patient and 2 eyes , 1 case of vitreous hemorrhage complicated with neovascular glaucoma, 1 case of optic disc edema (except RVO), 3 cases of 6 eyes. Nine cases had ocular opacity, 21 cases had systemic symptoms, all cases had anti-nuclear antinuclear antibody (ANA), anti-dsDNA positive and ESR, 19 cases of C3 decreased and 17 cases of C4 decreased. Conclusion SL E can cause serious complications of ocular fundus and other ocular lesions. Patients with SL E should have regular ophthalmological examinations to detect retinal lesions early and treat them promptly.