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目的：细胞粘附蛋白（Ａｄｈｅｓｉｏｎ Ｐｒｏｔｅｉｎ，ＡＰｓ）是一种广泛分布于体内的糖蛋白，种类繁多。此研究分析了ＡＰｓ 中的血管性假血友病因子相关抗原（ｖＷＦ：Ａｇ） 、纤维连结蛋白（Ｆｎ）及纤维蛋白原（Ｆｇ） 三项指标与肺癌的相关性。方法：上述三项指标均采用免疫火箭电泳方法，对２１５ 例肺癌患者和４８ 例肺良性疾病患者进行检测。结果：肺癌患者血浆中上述三项指标水平均高于肺良性疾病，并有统计学意义，Ｐ＜ ０ ．００１。肺癌组不同的治疗方式对血浆ｖＷＦ：Ａｇ、Ｆｎ 和Ｆｇ 的水平具有一定的影响。手术组和化疗组的上述三项指标治疗前后的分布差异有高度显著性，Ｐ＜ ０ ．００１。而放疗组只有血浆Ｆｎ 治疗前后差异有统计学意义，Ｐ＜ ０ ．０１ 。姑息性治疗血浆ｖ ＷＦ：Ａｇ、Ｆｎ 和Ｆｇ 治疗前后均无统计学差异。结论：ＡＰｓ 中的ｖＷＦ：Ａｇ、Ｆｎ 、Ｆｇ 与肺癌的存在具有一定的相关性，可作为肺癌的检测手段之一。
OBJECTIVE: Adhesion proteins (APs) are widely distributed glycoproteins in the body. This study analyzed the association of von Willebrand factor-related antigen (vWF:Ag), fibronectin (Fn), and fibrinogen (Fg) in lung cancer with APs. Methods: All the above three indicators were tested by immunoelectromagnetic rocket electrophoresis and 215 patients with lung cancer and 48 patients with benign lung disease were examined. Results: The above-mentioned three indicators in plasma of patients with lung cancer were higher than those of benign lung disease, with statistical significance, P < 0. 001. Different treatment methods in the lung cancer group have a certain influence on plasma vWF:Ag, Fn and Fg levels. The distribution of the above three indicators before and after treatment in the surgery group and the chemotherapy group was highly significant, P<0. 001. The radiotherapy group only had statistical significance before and after plasma Fn treatment, P < 0. 01. Palliative treatment plasma v WF: Ag, Fn and Fg were not statistically different before and after treatment. CONCLUSIONS: The vWF:Ag, Fn, and Fg in APs have a certain correlation with the presence of lung cancer and may be used as one of the detection methods for lung cancer.