论文部分内容阅读
目的:细胞粘附蛋白(Adhesion Protein,APs)是一种广泛分布于体内的糖蛋白,种类繁多。此研究分析了APs 中的血管性假血友病因子相关抗原(vWF:Ag) 、纤维连结蛋白(Fn)及纤维蛋白原(Fg) 三项指标与肺癌的相关性。方法:上述三项指标均采用免疫火箭电泳方法,对215 例肺癌患者和48 例肺良性疾病患者进行检测。结果:肺癌患者血浆中上述三项指标水平均高于肺良性疾病,并有统计学意义,P< 0 .001。肺癌组不同的治疗方式对血浆vWF:Ag、Fn 和Fg 的水平具有一定的影响。手术组和化疗组的上述三项指标治疗前后的分布差异有高度显著性,P< 0 .001。而放疗组只有血浆Fn 治疗前后差异有统计学意义,P< 0 .01 。姑息性治疗血浆v WF:Ag、Fn 和Fg 治疗前后均无统计学差异。结论:APs 中的vWF:Ag、Fn 、Fg 与肺癌的存在具有一定的相关性,可作为肺癌的检测手段之一。
OBJECTIVE: Adhesion proteins (APs) are widely distributed glycoproteins in the body. This study analyzed the association of von Willebrand factor-related antigen (vWF:Ag), fibronectin (Fn), and fibrinogen (Fg) in lung cancer with APs. Methods: All the above three indicators were tested by immunoelectromagnetic rocket electrophoresis and 215 patients with lung cancer and 48 patients with benign lung disease were examined. Results: The above-mentioned three indicators in plasma of patients with lung cancer were higher than those of benign lung disease, with statistical significance, P < 0. 001. Different treatment methods in the lung cancer group have a certain influence on plasma vWF:Ag, Fn and Fg levels. The distribution of the above three indicators before and after treatment in the surgery group and the chemotherapy group was highly significant, P<0. 001. The radiotherapy group only had statistical significance before and after plasma Fn treatment, P < 0. 01. Palliative treatment plasma v WF: Ag, Fn and Fg were not statistically different before and after treatment. CONCLUSIONS: The vWF:Ag, Fn, and Fg in APs have a certain correlation with the presence of lung cancer and may be used as one of the detection methods for lung cancer.