３３例高血压病左室肥厚（ＬＶＨ）患者，用缓释异搏定治疗一年，定期检测左室重量指数（ＬＶＭＩ）和淋巴细胞［Ｃａ２＋］ｉ。结果发现：①ＬＶＭＩ和［Ｃａ２＋］ｉ在治疗６个月时明显降低；②ＬＶＭＩ与［Ｃａ２＋］ｉ，ＭＡＰ呈正相关；③治疗一年，△ＬＶＭＩ与△［Ｃａ２＋］ｉ，△ＭＡＰ呈正相关（Ｐ＜０．０１）。表明缓释异搏定逆转ＬＶＨ的机制除血压下降的作用外，［Ｃａ２＋］ｉ降低是一个非常重要的因素。 Thirty-three hypertensive left ventricular hypertrophy (LVH) patients were treated with sustained-release verapamil for one year, and LVMI and lymphocyte [Ca2 +] i were measured regularly. The results showed that: (1) LVMI and [Ca2 +] i were significantly decreased at 6 months of treatment; ②LVMI was positively correlated with [Ca2 +] i and MAP; ③ After treatment, △ LVMI was positively correlated with △ [Ca2 +] i and △ MAP 0.01). It is indicated that the mechanism of slow release of verapamil to reverse LVH is a very important factor besides the decrease of blood pressure, and the decrease of [Ca2 +] i.