论文部分内容阅读
目的:观察非生物型人工肝支持系统血浆置换治疗高原地区慢性重型肝炎支持疗效。方法:分析2006年9月—2007年8月我科行人工肝血浆置换治疗的16例慢性重型肝炎(来自我省不同海拔高度地区2000m~3680m),共治疗38人次,平均每例患者(1~4)次。观察治疗前后肝功谷丙转氨酶(ALT)、血清总胆红素(TBIL)、血清白蛋白(ALB)、凝血酶原时间及活动度(PT、PTA),血氨(NH3)等生化指标及临床症状。结果:每次治疗后患者的谷丙转氨酶、血清总胆红素、血氨均明显下降,凝血酶原时间缩短,血清白蛋白及凝血酶原活动度显著提高,患者的临床症状有不同程度改善。结论:非生物型人工肝支持系统能有效改善高原地区慢性重型肝炎患者的临床症状及生化指标,防止因高原低氧环境导致的肝细胞坏死进一步加重,为肝细胞的再生修复及肝移植赢得了时间,是高原地区治疗重型肝炎的一种有效方法。
OBJECTIVE: To observe the efficacy of non-biological artificial liver support system plasma exchange in the treatment of chronic severe hepatitis in the plateau. Methods: From September 2006 to August 2007, 16 cases of chronic severe hepatitis (from 2000m to 3680m at different altitudes in our province) treated by artificial liver plasma exchange in our department were treated for a total of 38 times, with an average of 1 ~ 4) times. The biochemical indexes such as ALT, TBIL, ALB, PT, PTA and NH3 were observed before and after treatment. Clinical symptoms. Results: The alanine aminotransferase, serum total bilirubin and blood ammonia were significantly decreased after each treatment, the prothrombin time was shortened, the activities of serum albumin and prothrombin were significantly increased, and the clinical symptoms of patients were improved to some extent . CONCLUSION: Abiotic-type artificial liver support system can effectively improve the clinical symptoms and biochemical indexes of patients with chronic severe hepatitis in the plateau area and prevent further aggravation of hepatocyte necrosis caused by plateau hypoxia environment, which has won the promise of regenerative repair and liver transplantation of hepatocytes Time is an effective method for treating severe hepatitis in the plateau area.