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用５－ＨＴ抗体和５－ＨＴ抗独特型抗体的免疫组织化学反应，研究了５－ＨＴ及５－ＨＴ受体在大鼠颌下腺的分布。雄性大鼠颌下腺的浆液性腺泡的腺上皮细胞、各级导管的上皮细胞、颌下腺内副交感神经节细胞、毛细血管及小血管的内皮细胞均呈５－ＨＴ和５－ＨＴ受体免疫反应阳性。但是，雌性大鼠的颌下腺只有一些导管的上皮细胞呈５－ＨＴ和５－ＨＴ受体免疫反应阳性。以上结果提示，５－ＨＴ及５－ＨＴ受体在雄性大鼠颌下腺的分布比在雌性大鼠的广泛，大鼠颌下腺内所有５－ＨＴ阳性细胞都可能具有自分泌５－ＨＴ的功能。
The distribution of 5-HT and 5-HT receptors in the submandibular gland of rats was studied by immunohistochemistry with 5-HT and 5-HT anti-idiotypic antibodies. 5-HT and 5-HT receptor immunoreactivity were positive in the glandular epithelial cells of the submandibular gland of male rats, the epithelial cells of the catheters at various levels, the parasympathetic ganglion cells in the submandibular glands, the endothelial cells of capillaries and small vessels. However, only some of the ductal epithelial cells in the submandibular gland of female rats were immunoreactive with 5-HT and 5-HT receptors. The above results suggest that the distribution of 5-HT and 5-HT receptors in the submandibular gland of male rats may be more autocrine 5-HT than all of the 5-HT positive cells in the submandibular glands of rats.