色甘酸二钠 (disodium cromoglycate,DSCG) 近十几年来临床研究有较大进展,随着药理学的研究及与过敏有关疾病的进一步了解,大大推动了DSCG的临床应用,现将有关色甘醚二钠的作用机理研究和临床应用作一综述,并简介色羟丙钠(sodium crompromate)的作用。 作用机制研究 在I型变态反应时,抗原架桥于IgE上,激活肥大细胞或嗜碱细胞膜上IgE受体,膜变构及相应蛋白水解酶激活,磷脂甲基化,cAMP单向上升, Disodium cromoglycate (DSCG) has made great progress in clinical research over the past decade. With the further study of pharmacology and further understanding of allergic diseases, it has greatly promoted the clinical application of DSCG. The mechanism of action of disodium and clinical application are reviewed, and the role of sodium crompromate. Mechanism of action In the type I allergic reaction, antigenic bridging on IgE, activation of mast cells or basophil IgE receptors, membrane structure and the corresponding protease activation, phospholipid methylation, cAMP increased one-way,