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目的:探讨对不同妊娠时期的潜伏梅毒孕妇进行驱梅治疗后对其新生儿的影响。方法:对早、中、晚妊娠并发潜伏梅毒的50例孕妇分别进行驱梅治疗,于新生儿出生一个月内进行梅毒快速反应试验(RPR)、梅毒螺旋体颗粒凝集试验(TPPA)和梅毒IgM(TP-IgM)检测,比较新生儿先天性梅毒的发病状况,并与13例未经治疗的潜伏梅毒妊娠所生新生儿的检测结果相对照。结果:不同时期妊娠并发潜伏梅毒经驱梅治疗后,新生儿先天性梅毒的发生率分别为5.00%、14.29%、35.71%,而未经治疗的潜伏梅毒孕妇所生新生儿先天性梅毒的发生率为76.92%,差异有统计学意义(P<0.05)。结论:及早对孕妇进行梅毒血清学筛查并及时对潜伏梅毒孕妇进行驱梅治疗是降低新生儿先天性梅毒发病率的关键。
Objective: To investigate the impact of pregnant women with latent syphilis in different stages of pregnancy on their newborns after they were treated with plum blossom. Methods: Fifty pregnant women with latent syphilis in early pregnancy, middle and late pregnancy were treated with plum blossom therapy respectively. The syphilis rapid response test (RPR), syphilis spirochete particle agglutination test (TPPA) and syphilis IgM TP-IgM) test to compare neonatal congenital syphilis incidence, and with 13 cases of untreated latent syphilis pregnancy neonatal test results. Results: The incidence of congenital syphilis in newborns was 5.00%, 14.29% and 35.71% respectively after pregnant with syphilis in different stages of pregnancy. The incidence of congenital syphilis in untreated pregnant women with latent syphilis The rate was 76.92%, the difference was statistically significant (P <0.05). Conclusion: Early screening of pregnant women for syphilis serology and prompt treatment of latent syphilis in pregnant women is the key to reduce the incidence of neonatal congenital syphilis.