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目的分析厦门大学附属中山医院近年来急性髓性白血病的发病情况与趋势,从中了解本地区急性髓性白血病的流行趋势,为制定科学的防治方法提供依据。方法回顾性分析2005~2012年厦门大学附属中山医院就诊的初发急性髓性白血病病例资料,统计分析年龄、性别、亚型及疗效的差异。结果新发急性髓性白血病患者的男女比例相当,无差异,25至59岁的中青年为高发病人群,其中35至39岁年龄段最高发,75到79岁出现老年人发病小高峰;M2、M3、M5是发病人数最多的三个亚型,且在未成年人、成年人、老年人不同年龄段组的发病比例有显著差异;2005~2012年新增患者人数具有上升趋势。结论 2005~2012年本院新发急性髓性白血病人数呈上升趋势,不同年龄段新发病例疗效差异显著可能与疾病亚型相关。
Objective To analyze the incidence and trend of acute myeloid leukemia in Zhongshan Hospital Affiliated to Xiamen University in recent years and to find out the epidemic trend of acute myeloid leukemia in this area and provide the basis for the formulation of scientific prevention and treatment methods. Methods The data of primary acute myeloid leukemia patients admitted to Zhongshan Hospital Affiliated to Xiamen University from 2005 to 2012 were retrospectively analyzed. The differences of age, sex, subtypes and therapeutic effect were analyzed statistically. Results The proportion of newly diagnosed acute myeloid leukemia patients was quite high, with no difference. The middle-aged and young people aged 25-59 years were the highest incidence, of which 35-39 years old had the highest incidence, and 75-79 years old had a small peak of incidence of the elderly. M2 , M3 and M5 are the three subtypes with the largest number of cases, and there is a significant difference in the incidence rates among different age groups among minors, adults and seniors; the number of new patients in 2005 ~ 2012 is on the rise. Conclusions The number of new-onset acute myeloid leukemia in our hospital from 2005 to 2012 is on the rise. The differences in the efficacy of new-onset cases at different ages may be related to the disease subtype.