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目的探讨农村妇女宫颈癌前病变筛查的结果及预防干预对策。方法选择2014年7月-2016年12月抚宁区农村妇女9 000例为研究对象,其中3 000例行液基薄层细胞(TCT)检测的妇女为TCT组,3 000例行人乳头瘤病毒(HPV)16/18型检测的妇女为HPV组,3 000例行TCT联合HPV 16/18型检测的妇女为联合组,并对所有妇女行阴道镜下活检,以组织学检查为金标准,比较3组阳性检出率和组织学诊断符合率的差异。结果联合检测宫颈病变的检出率高于TCT检测和HPV16/18型检测,差异有统计学意义(P<0.05);联合检测诊断的敏感性、特异性、阳性预测值及阴性预测值均明显高于TCT检测和HPV 16/18型检测,差异有统计学意义(P<0.05)。结论联合检测可提高宫颈病变检出率,有利于体检时早期发现宫颈病变,以便积极治疗并防止恶变。
Objective To investigate the results of screening cervical precancerous lesions in rural women and preventive measures. Methods Nine thousand rural women in Funing District from July 2014 to December 2016 were selected as the research objects. Among them, 3 000 women who underwent liquid-based thin-layer cells (TCT) test were TCT group, 3 000 were human papilloma Women of the HPV (HPV) 16/18 type tested for the HPV group, 3 000 women for the TCT combined with the HPV 16/18 type tested as a combined group, and colposcopic biopsy was performed for all women with histological examination as the gold standard , The difference between the positive detection rate of 3 groups and the coincidence rate of histological diagnosis was compared. Results The detection rate of combined detection of cervical lesions was higher than that of TCT and HPV16 / 18, the difference was statistically significant (P <0.05). The sensitivity, specificity, positive predictive value and negative predictive value of combined detection were significantly higher Higher than TCT test and HPV 16/18 test, the difference was statistically significant (P <0.05). Conclusion Combined detection can improve the detection rate of cervical lesions, early detection of cervical lesions conducive to physical examination in order to actively treat and prevent malignant transformation.