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梭曼中毒难以防治的关键问题是胆碱酯酶(ACHE)磷酰化后很快老化,不易重活化。迄今为止尚未找到有效的重活化剂。值得注意的是,梭曼抑制 AChE 的程度与中毒症状的轻重有时并不呈现平行关系。如:中毒大鼠的症状有轻有重而 AChE 的抑制程度相似,或者症状业已消失但 AChE 仍被持续抑制。在人,梭曼急性中毒经阿托品及氯磷啶治疗后第三天即可起床活动而10天后红血球 AChE 仍抑制88%。众所周知,中毒后
The key problem that is difficult to control by Soman’s poisoning is the rapid aging of ACHE phosphorylation, which is not easily reactivated. To date, no effective reactivator has been found. It is worth noting that the degree of inhibition of AChE by soman does not always show a parallel relationship with the severity of symptoms of poisoning. Such as: poisoning rats have mild to severe symptoms and similar inhibition of AChE, or symptoms have disappeared but AChE is still sustained inhibition. In humans, soman acute poisoning by atropine and chlorophosphon treatment after the third day to get up and 10 days after the inhibition of red blood cells AChE still 88%. As we all know, after poisoning