氟化钠治疗进行性感觉神经性聋耳硬化症,首先由Shambaugh等(1964)提出,其后Linthicum等(1973)用放射性同位素证明约有50％病例经氟化钠治疗,可抑制硬化灶内的成骨细胞活性。Causse等又研究指出,氟化钠可降低海绵样骨质中酶的活性,并减少引起感觉神经性聋毒性酶的总量。据认为导致感觉神经性聋的首要原因是蛋白分解酶蔓延至内耳淋巴液,此酶来自耳蜗外侧壁耳硬化微小病灶 Sodium fluoride for the treatment of progressive deafness-induced otosclerosis was first proposed by Shambaugh et al. (1964). Later, Linthicum et al. (1973) used radioisotopes to prove that about 50% of cases were treated with sodium fluoride and inhibited the development of sclerosis Osteoblast activity. Causse et al. Have also shown that sodium fluoride reduces the activity of enzymes in cambium-like scaffolds and decreases the total amount of enzymes that cause deafness in sensory neurons. It is believed that the primary cause of sensory nerve deafness is the spread of proteolytic enzymes to the inner ear lymph, which is derived from the small lesions of the lateral wall of the ear