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目前 ,缓控释制剂的技术发展主要有以下几个方面 :每日一次给药系统、恒速释放、定位和定时释放技术等 ,本文综述了这些给药系统的原理及研究进展。通过改变片剂的几何外形可达到恒速释放的目的 ,介绍了迭层扩散骨架片、双凹形带孔包衣片、环形片 ;定位释药技术研究较多的是胃内滞留系统及结肠定位释药 ;定时释放即脉冲式给药系统 ,包括脉冲释药片、脉冲释药微丸及热控制脉冲式给药系统。
At present, the technical development of controlled release formulations mainly includes the following aspects: once-daily drug delivery system, constant-speed release, positioning and time-release technologies, etc. The principles and research progress of these drug delivery systems are reviewed in this paper. By changing the geometric shape of tablets can achieve the purpose of constant rate of release, introduced laminated diffuse matrix tablets, biconcave perforated coated tablets, annular tablets; positioning release drug technology research is more gastric retention system and colon Positioning release drug; timing release that is pulsed delivery system, including pulse release tablets, pulse release pellets and thermal control pulse delivery system.