对离子液体介质中微波辐射下芳香醛、吡啶(喃)酮和丙二腈的三组分缩合反应的研究发现,该反应可快速完成,无需使用催化剂,并以较高的收率生成相应的吡喃并[3,2-c]吡啶酮和吡喃并[4,3-b]吡喃酮类化合物。与文献方法相比,该方法具有反应速度快、效率高、原料易得、对环境友好等优点。另外,该方法已成功地应用于吡喃并[3,2-c]吡啶酮和吡喃并[4,3-b]吡喃酮-嘧啶核苷杂化体的合成中。 A three component condensation reaction of aromatic aldehydes, pyridine (ketones) and malononitriles under microwave irradiation in an ionic liquid medium showed that the reaction can be completed rapidly without using a catalyst and generating corresponding Pyrano [3,2-c] pyridone and pyrano [4,3-b] pyrone compounds. Compared with the literature method, the method has the advantages of fast reaction rate, high efficiency, easy availability of raw materials, environmental friendliness and the like. In addition, this method has been successfully applied to the synthesis of pyrano [3,2-c] pyridone and pyrano [4,3-b] pyrone-pyrimidine nucleoside hybrids.