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目的:观察自拟复方中药联合替吉奥治疗晚期结直肠癌的临床疗效及毒副反应。方法:选择晚期结直肠癌术后化疗患者40例,随机分为治疗组和对照组各20例,治疗组采用自拟复方中药联合替吉奥治疗,对照组单纯采用FOLFOX4方案化疗。比较两组患者化疗前后生存质量改善情况、血清肿瘤标记物(CEA、CA19-9、CA72-4)、肿瘤坏死因子-α(TNF-α)及白介素-12(IL-12)含量以及血常规、肝肾功及心电图等相关检查指标的变化情况。结果:经过治疗,治疗组在降低血清肿瘤标记物CEA、CA19-9,优于对照组,且可明显改善患者生存质量,治疗组化疗后TNF-α及IL-12升高,而对照组降低,组间比较差异有统计学意义(P<0.05)。结论:自拟复方中药联合替吉奥对化疗毒副反应具有一定的防治作用,并能降低血清肿瘤标记物水平,同时可以改善患者临床症状和机体一般状况,值得临床推广应用。
Objective: To observe the clinical efficacy and side effects of self-made compound traditional Chinese medicine combined with tigiao in the treatment of advanced colorectal cancer. Methods: Forty patients with postoperative chemotherapy for advanced colorectal cancer were randomly divided into treatment group (n = 20) and control group (n = 20). The treatment group was treated with self-made compound traditional Chinese medicine combined with tigiao treatment, while the control group was treated with FOLFOX4 chemotherapy alone. The quality of life before and after chemotherapy was compared between the two groups. Serum tumor markers (CEA, CA19-9 and CA72-4), tumor necrosis factor-α (TNF-α) and interleukin-12 (IL-12) , Liver and kidney function and ECG and other related indicators of the inspection changes. Results: After treatment, the treatment group decreased serum tumor markers CEA, CA19-9, better than the control group, and can significantly improve the quality of life of patients in the treatment group after chemotherapy TNF-α and IL-12 increased, while the control group decreased , There was significant difference between groups (P <0.05). Conclusion: The combination of compound traditional Chinese medicine and Chinese medicine for the treatment of chemotherapy side effects have a certain role in prevention and treatment, and can reduce the level of serum tumor markers, and can improve the clinical symptoms and general condition of patients, worthy of clinical application.