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AIM:To investigate the association between curative effectsof interferon-α and partial human leucocyte antigen(HLA)II alleles in chronic viral hepatitis B.METHODS:Sixty patients with chronic viral hepatitis B inShanghai were treated with a standard course of treatmentwith interferon-α for 6 mo.HLA-DRB1,-DQA1,and-DQB1alleles were detected by polymerase chain reaction-sequencespecific primer(PCR-SSP)method.RESULTS:Frequencies of HLA-DRBI~*04(P<0.025)andHLA-DQA1~*0303(P<0.01) in non-responders weresignificantly higher than those in partial and completeresponders.Frequencies of HLA-DQA1~*0505(P<0.025)andHLA-DQB1~*0301(P<0.005)in partial and completeresponders were significantly higher than those in non-responders.CONCLUSION:Non-response to interferon-α therapy ispositively correlated with HLA-DRB1~*04 and HLA-DQA1~*0303,and negatively correlated with HLA-DQA1~*0505and-DQB1~*0301 in patient with chronic viral hepatitis B.HLA II genes of the identification alleles provide a methodfor evaluating outcome of interferon-α treatment.
To investigate the association between curative effects of interferon-alpha and partial human leucocyte antigen (HLA) II alleles in chronic viral hepatitis B. METHODS: Sixty patients with chronic viral hepatitis B in Shanghai were treated with a standard course of treatment with interferon-alpha for HLA-DRB1, -DQA1, and-DQB1alleles were detected by polymerase chain reaction-sequencespecific primer (PCR-SSP) method.Results: Frequencies of HLA-DRBI ~ * 04 (P <0.025) and HLA-DQA1 ~ * 0303 (P <0.01) in non-responders weresignificantly higher than those in partial and completeresponders.Frequencies of HLA-DQA1 ~ * 0505 (P <0.025) andHLA-DQB1 ~ * 0301 (P <0.005) in partial and completeresponders were significantly higher than Those in non-responders. CONCLUSION: Non-response to interferon-α therapy ispositively correlated with HLA-DRB1 * 04 and HLA-DQA1 ~ * 0303 and negatively correlated with HLA-DQA1 ~ * 0505 and-DQB1 ~ * 0301 in patient with chronic viral hepatitis B. HLA II genes of the identification alleles provide a method for eval uating outcome of interferon-α treatment.