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目的考察复方氯霉素阴道栓的稳定性。方法复方氯霉素阴道栓中氯霉素、甲硝唑含量采用高效液相色谱法测定;冰片含量采用气相色谱内标法测定;并用经典恒温法探讨复方氯霉素阴道栓的稳定性。结果复方氯霉素阴道栓的降解反应符合一级动力学,室温保存,有效期为1.7 a。结论所用方法准确可靠,可用于本制剂的稳定性考察。
Objective To investigate the stability of compound chloramphenicol vaginal suppository. Methods The contents of chloramphenicol and metronidazole in compound chloramphenicol vaginal suppository were determined by high performance liquid chromatography. The content of borneol was determined by gas chromatography internal standard method. The stability of compound chloramphenicol vaginal suppository was studied by classical thermostat method. Results Compound chloramphenicol vaginal suppository was in accordance with the first order kinetics and stored at room temperature for a period of 1.7 years. Conclusion The method used is accurate and reliable and can be used for the stability study of this preparation.