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目的:观察培美曲塞二钠联合铂类药物治疗浆膜腔转移癌的近期临床疗效及毒性反应。方法:6例住院治疗的浆膜腔转移癌患者均经细胞学病理学检查确诊。采用培美曲塞二钠联合铂类药物化疗后评价疗效。结果:6例患者均可评价,获得完全缓解(CR)2例,部分缓解(PR)3例,稳定(SD)1例,有效率为83.3%(5/6),主要的毒副反应是骨髓抑制(Ⅰ度)和消化道反应,均可耐受,经对症处理症状消失。结论:培美曲塞二钠联合铂类药物治疗多浆膜腔转移癌患者的疗效较好,明显提高生活质量,延长了生存期,而且毒副反应轻,患者耐受性好。
Objective: To observe the recent clinical efficacy and toxicity of pemetrexed disodium combined with platinum-based drug in the treatment of metastatic carcinoma of the serous cavity. Methods: Six patients with serous cystadenocarcinoma hospitalized were diagnosed by cytology and pathology. The use of pemetrexed disodium platinum combined with chemotherapy after the evaluation of efficacy. Results: All of the 6 patients were evaluated. Two patients had complete remission (CR), three had partial remission (PR), and one had stable (SD). The effective rate was 83.3% (5/6). The main toxicities were Myelosuppression (Ⅰ degree) and gastrointestinal reactions, can be tolerated, symptomatic treatment of symptoms disappear. Conclusions: Pemetrexed disodium combined with platinum-based drugs is effective in treating patients with mucosal metastasis and significantly improves the quality of life and prolongs the survival period. The patients also have mild toxicity and good patient tolerance.