本文研究缺氧时幼猪和猕猴血浆TXB_2和6-keto-PGF1α浓度变化,以探讨血栓素A_2(TXA_2)和前列环素(PGI_2)在缺氧性肺血管收缩反应(HPV)中的作用。结果:当急性肺泡缺氧时,幼猪肺产生TXA_2和PGI_2,而猕猴肺只产生PGI_2,消炎痛能加强这两种动物的缺氧性肺血管收缩反应。由此表明,幼猪和猕猴的HPV主要由前列腺素以外的因素介导。虽然TXA_2和PGI_2在HPV时变化不同,但其总效应都起调节作用。 This study was designed to investigate the changes of TXB_2 and 6-keto-PGF1α in neonatal pigs and macaques during hypoxia to explore the role of TXA_2 and PGI_2 in hypoxic pulmonary vasoconstriction (HPV). RESULTS: In acute alveolar hypoxia, piglets developed TXA_2 and PGI_2 in the lungs, while PGI_2 was produced in the lungs of the monkeys. Indomethacin enhanced the hypoxic pulmonary vasoconstriction in both animals. Thus, HPV in young pigs and macaques is mainly mediated by factors other than prostaglandins. Although the changes of TXA_2 and PGI_2 in HPV are different, their total effects play a regulatory role.