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目的:优选栝蒌根丸水提取的最佳工艺。方法:采用4因素3水平正交设计,高效液相色谱法测定小檗碱含量,以提取物中小檗碱含量为检测指标,筛选出栝蒌根丸的优化提取条件。结果:栝蒌根丸的最佳水提取工艺为加10倍量水煎煮2.0 h,提取2次。结论:栝蒌根丸水提取工艺工艺简单、易于操作、不使用有机溶剂、成本低廉。
Objective: To optimize the best technology for the extraction of Radix Paeoniae Alba. Methods: The content of berberine was determined by orthogonal design with 4 factors and 3 levels and high performance liquid chromatography (HPLC). The content of berberine in the extract was taken as the detection index, and the optimized extraction conditions were obtained. Results: The optimum water extraction technology of Zaocao root pills was boiling water with 10 times of water for 2.0 h and extracting twice. Conclusion: The technology of water extract of Ziziphus officinalis is simple, easy to operate, does not use organic solvents and has low cost.