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在过去的40年中发现了大量抗生素,并且采用了许多新方法发现了新抗生素。其方法之一就是使用对抗生素高度敏感的突变株。近年来应用于新抗筛选的有大肠杆菌和绿脓杆菌的β-内酰胺类超敏突变株,肺炎克雷伯氏菌的氨基糖苷类超敏突变株。环丝氨酸具有广抗菌谱,并且对丙氨酸消旋酶(EC5.1.1.1)和丙氨酸:D-丙氨酸连接酶(EC6.3.2.4)起作用。这些酶涉及到细菌细胞壁粘肽层的合成。抗生素MK641/MK642和alaphosphin也与其相似的
Numerous antibiotics have been found in the past 40 years and many new methods have been used to find new antibiotics. One way to do this is to use mutants that are highly susceptible to antibiotics. In recent years, applied to the new anti-screening of Escherichia coli and Pseudomonas aeruginosa β-lactam hypersensitive mutant, Klebsiella pneumoniae aminoglycoside hypersensitive mutant. Cycloserines have a broad antimicrobial spectrum and act on alanine racemase (EC5.1.1.1) and alanine: D-alanine ligase (EC 6.3.2.4). These enzymes are involved in the synthesis of bacterial cell wall muco-peptide layers. The antibiotics MK641 / MK642 and alaphosphin are similar