左卡尼汀提高大鼠心肌梗死后移植骨髓间充质干细胞的存活和作用

来源 :中国心血管病研究 | 被引量 : 0次 | 上传用户：wuhaoxust

【摘要】

：

目的探讨左卡尼汀(LC)是否能提高心肌梗死后移植骨髓间充质干细胞(MSCs)的存活率,从而提高其疗效.方法 60只大鼠随机分为5组:假手术组、模型组、LC组、MSCs组和左卡尼汀联合

【作者】

：

李培蕾林明许昌声

【机构】

：

福建医科大学附属第一医院心血管内科,福建省高血压研究所

【出处】

：

中国心血管病研究

【发表日期】

：

2004年期

【关键词】

：

心肌梗死左卡尼汀骨髓间充质干细胞细胞移植

【基金项目】

：

福建医科大学教授基金;

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目的探讨左卡尼汀(LC)是否能提高心肌梗死后移植骨髓间充质干细胞(MSCs)的存活率,从而提高其疗效.方法 60只大鼠随机分为5组:假手术组、模型组、LC组、MSCs组和左卡尼汀联合骨髓间充质干细胞(LC+MSCs)组.4周后检测心功能、MSCs存活情况和梗死区心肌纤维化水平.结果 4周后,与MSCs组比较,LC+MSCs组MSCs的存活、左室心功能、心肌纤维化均改善(P.＜0.05).结论 LC联合MSCs使用可提高MSCs的存活率,更好地改善心肌梗死后的心功能和心肌纤维化.

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左卡尼汀提高大鼠心肌梗死后移植骨髓间充质干细胞的存活和作用

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