自70年代以来人们发现许多人类实体瘤被大量单核细胞(MNC)浸润或包围,这些浸润的MNC对肿瘤的生长和转移以及对肿瘤患者生存期的影响是人们争议的对象。近些年研究发现头颈肿瘤局部微环境中存在免疫抑制因子,同时发现NK细胞的活性降低,细胞间粘连分子(ICAM Since the 1970s, many human solid tumors have been found to be infiltrated or surrounded by a large number of mononuclear cells (MNCs). These infiltrated MNCs have been the subject of controversy on the growth and metastasis of tumors and on the survival of tumor patients. In recent years, it has been found that immunosuppressive factors exist in the local microenvironment of head and neck neoplasms. At the same time, the activity of NK cells has been found to decrease, intercellular adhesion molecules (ICAM).