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[目的]探讨人乳头状瘤病毒(HPV)L1壳蛋白在维、汉族HPV阳性宫颈不同病变脱落细胞中的表达。[方法]收集宫颈脱落细胞标本300例,维吾尔族妇女129例:慢性宫颈炎64例(49%),CIN1 24例(19%),CIN2/3 26例(20%),宫颈癌15例(12%);汉族妇女171例:慢性宫颈炎83例(48%),CIN1 39例(23%),CIN2/3 39例(23%),宫颈癌10例(6%)。采用免疫细胞化学法检测HPV L1壳蛋白在宫颈脱落细胞中的表达。[结果]维吾尔族妇女L1的表达阳性率为:慢性宫颈炎31%(20/64),CIN1 63%(15/24),CIN2/3 27%(7/26),宫颈癌中无表达,各组间比较差异有统计学意义(χ2=17.466,P=0.01),且随病变程度加重(CIN到宫颈癌),HPV L1壳蛋白阳性表达率呈下降趋势。汉族妇女L1蛋白表达阳性率:慢性宫颈炎39%(32/83),CIN1 59%(23/39),CIN2/326%(10/39),宫颈癌中无表达。维吾尔族妇女与汉族妇女同级别宫颈病变间L1表达率差异均无统计学意义(P均>0.05)。[结论]HPV L1壳蛋白在宫颈病变中的阳性表达率随着病变程度加重呈下降趋势(CIN到宫颈癌),有望成为预测宫颈癌前病变进展的生物标志物。HPV L1壳蛋白在维、汉族同级别宫颈病变间的表达无差异。
[Objective] To investigate the expression of human papillomavirus (HPV) L1 capsid protein in exfoliated cells of different cervical lesions of HPV and Han ethnicity. [Methods] 300 samples of cervical exfoliated cells were collected and 129 Uyghur women were enrolled: 64 cases of chronic cervicitis (49%), 24 cases of CIN1 (19%), 26 cases of CIN2 / 3 (20%) and 15 cases of cervical cancer In Han women, there were 171 cases of chronic cervicitis: 83 cases (48%), CIN1 39 cases (23%), CIN2 / 39 cases (23%) and cervical cancer 10 cases (6%). Immunocytochemistry was used to detect the expression of HPV L1 capsid protein in cervical exfoliated cells. [Results] The positive expression rates of L1 in Uighur women were 31% (20/64) of chronic cervicitis, 63% (15/24) of CIN1, 27/27 (7/26) of CIN2 / cervical cancer, The difference between the two groups was statistically significant (χ2 = 17.466, P = 0.01). The positive rate of HPV L1 capsid protein decreased with the severity of the disease (CIN to cervical cancer). The positive expression rate of L1 protein in Han women was 39% (32/83) in chronic cervicitis, 59% (23/39) in CIN1, 326/326% in cervical cancer (10/39), and no expression in cervical cancer. There was no significant difference in L1 expression rate between Uyghur women and Han women at the same level (all P> 0.05). [Conclusion] The positive rate of HPV L1 capsid protein in cervical lesions shows a decreasing trend (CIN to cervical cancer) with the severity of the lesions, which is expected to become a biomarker to predict the progression of cervical precancerous lesions. The expression of HPV L1 capsid protein was not different between the same grade of cervical lesions in Victoria and Han nationality.