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现已确认肥胖、糖代谢异常、不育、绝经晚及使用外源性激素是绝经后期宫内膜癌的高危因素,但关于绝经前期的病因尚不明确。 年轻患者发生宫内膜癌与使用外源性雌激素及内源性雌激素水平紊乱有关。此时体内的雌激素无孕激素对抗或有微弱的孕激素对抗。文献中也陆续有关于性腺功能不全的患者在长期服用雌激素后发生宫内膜癌的报道。Lyon于1975年报道长期使用序贯避孕药后发生宫内膜癌。Dockerty于1951年报道卵巢多囊卵巢综合征患者发生宫内膜癌与长期不排卵有关。但也有相当多的患者,既未找到不排卵的原因,也未发现其它的病因。
Have been identified obesity, abnormal glucose metabolism, infertility, menopause and the use of exogenous hormones are risk factors for endometrial cancer in the postmenopausal period, but the etiopathogenisis is not yet clear. Endometrial cancer in young patients with the use of exogenous estrogen and endogenous levels of estrogen disorders. Estrogen at this time no progesterone or faint progesterone confrontation. There are also reports in the literature of endometrial cancer in patients with gonadal insufficiency after long-term use of estrogen. Lyon in 1975 reported long-term use of sequential contraceptives occurred after endometrial cancer. Dockerty reported in 1951 the occurrence of endometrial cancer in patients with ovarian polycystic ovary syndrome is associated with prolonged anovulation. However, there are quite a few patients who have not found the cause of anovulation and have not found other causes.