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目的观察分析晚期早产儿喂养不耐受的临床特点。方法选择2008—2010年在本院妇产科出生、胎龄34~36周的晚期早产儿60例为观察组、足月儿60例为对照组,测量两组患儿体重、身长、头围,观察喂养不耐受、呕吐、腹胀、胃潴留以及因喂养不耐受而延长住院时间的例数,比较两组胎粪排净时间、建立吸吮吞咽时间、直接喂哺母乳的时间及住院时间,观察两组低血糖症的发生率。结果观察组各生长发育指标均明显低于对照组[体重:(2330±760)g比(3240±920)g,身长:(48.4±4.3)cm比(51.9±2.5)cm,头围:(30.3±5.7)cm比(33.1±1.2)cm,P均<0.05],喂养不耐受相关临床表现发生的比例均高于对照组[喂养不耐受:46.7%比10.0%,呕吐:38.3%比6.7%,腹胀:10.0%比0,胃潴留:36.6%比5.0%,住院时间延长:28.3%比0,P均<0.05],胃肠功能完善的时间均明显长于对照组[排净胎粪:(3.6±1.2)天比(2.1±0.8)天,建立吞咽吸吮:(3.3±1.8)天比(1.7±0.3)天,直接喂哺母乳:(6.6±3.8)天比(1.5±0.7)天,P<0.01,住院时间长于对照组[(10.8±3.0)天比(5.3±1.8)天,P<0.01]。观察组低血糖的发生率明显高于对照组(15.0%比1.6%,P<0.05)。结论晚期早产儿喂养不耐受的发生率明显高于足月儿,与其体格、胃肠道及神经肌肉等各方面的发育仍不成熟有关,对这些患儿应给予更多的关注及研究。
Objective To observe the clinical features of feeding intolerance in advanced preterm infants. Methods From 2008 to 2010 in our hospital obstetrics and Gynecology, gestational age 34 to 36 weeks of late preterm children 60 cases of observation group, 60 cases of full-term children as control group, measuring the two groups of children weight, length, head circumference , Observe feeding intolerance, vomiting, bloating, gastric retention and prolonged hospitalization due to intolerance into the case of the number of cases, the two groups of meconium row net time, the establishment of sucking and swallowing time, breastfeeding time and hospitalization time , Observed the incidence of hypoglycemia in both groups. Results The growth and development indexes in the observation group were significantly lower than those in the control group [body weight: (2330 ± 760) g (3240 ± 920) g, body length: (48.4 ± 4.3) cm 30.3 ± 5.7 cm vs 33.1 ± 1.2 cm respectively (all P <0.05), and the proportion of feeding intolerance related clinical manifestations were higher than that of the control group [Feeding intolerance: 46.7% vs. 10.0%, Vomiting: 38.3% Abdominal distension: 10.0% vs 0, gastric retention: 36.6% vs 5.0%, length of hospital stay: 28.3% vs 0, P <0.05], and the time to complete gastrointestinal function was significantly longer than that of the control group Dung: (3.6 ± 1.2) days compared with (2.1 ± 0.8) days to establish swallowing suck: (3.3 ± 1.8) day than (1.7 ± 0.3) days, direct breastfeeding: (6.6 ± 3.8) ) Day, P <0.01, and the length of hospital stay was longer than that of the control group [(10.8 ± 3.0) days vs (5.3 ± 1.8) days, P <0.01]. The incidence of hypoglycemia in observation group was significantly higher than that in control group (15.0% vs. 1.6%, P <0.05). Conclusions The incidence of feeding intolerance in advanced preterm infants is significantly higher than that in term infants, which is not related to their physical, gastrointestinal and neuromuscular development. Therefore, more attention and study should be given to these infants.