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目的探讨联合应用血必净注射液治疗慢性肺源性心脏病急性期(AECPHD)患者的疗效。方法选择62例AECPHD患者,随机分为对照组(30例)和治疗组(32例)。对照组予以西医常规基础治疗;治疗组在对照组治疗基础上加用血必净注射液,连用7d。监测患者治疗前后血液流变学、血细胞数和C反应蛋白等指标,并记录患者的住院时间。结果与治疗前比较,治疗组患者治疗后全血高、低切黏度、血细胞比容、血细胞和C反应蛋白均有明显改善(P<0.05或P<0.01);治疗组治疗前后全血高、低切黏度及血细胞的变化程度较对照组更明显,差异有统计学意义(P均<0.05)。治疗组患者症状缓解时间及住院时间较对照组明显缩短,差异有统计学意义(P<0.05)。结论联合应用血必净注射液治疗AECPHD患者对提高疗效有一定的作用。
Objective To investigate the curative effect of combined application of Xuebijing injection on acute phase of chronic cor pulmonale (AECPHD). Methods Sixty-two AECPHD patients were randomly divided into control group (n = 30) and treatment group (n = 32). The control group was given western medicine routine basic treatment; the treatment group was treated with Xuebijing injection on the basis of the control group for 7 days. Monitoring patients before and after treatment of hemorheology, blood cell count and C-reactive protein and other indicators, and record the patient’s hospital stay. Results Compared with those before treatment, the treatment group showed a significant improvement in whole blood high and low shear viscosity, hematocrit, blood cells and C-reactive protein (P <0.05 or P <0.01) Low viscosity and blood cell changes in the degree of more obvious than the control group, the difference was statistically significant (P all <0.05). The symptom relieving time and hospitalization time in the treatment group were significantly shorter than those in the control group (P <0.05). Conclusion The combination of Xuebijing injection in patients with AECPHD treatment to improve the effect of a certain extent.