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目的 探讨大柴胡汤的利胆作用与时辰及剂量的关系。方法 弥猴 4只 ,雌性 ,通过以不同剂量大柴胡汤对实验猴及空白对照猴取不同时辰分泌的胆汁量及其成份进行分析。结果 (1)利胆作用 ,大剂量组利胆作用明显 ,胆汁量和胆汁酸含量与空白对照组比较有显著差异 (P<0 .0 5 ) ,而小剂量组胆汁量低于对照组 ,差异显著 (P<0 .0 5 )。 (2 )胆固醇含量和胆红素含量 ,大剂量组与对照组相比明显降低 ,有显著差异 (P<0 .0 5 ) ;子丑段、戍亥段用药胆酸量增加。结论 大柴胡汤治疗量要用大剂量才能增加胆汁分泌和胆汁酸含量 ,降低胆红素、胆固醇的合成 ,保证药物的疗效。
Objective To explore the relationship between the choleretic effect of Dachaihu Decoction and the time and dose. Methods Four female monkeys, females, were used to analyze the amount of bile secreted by the monkeys and blank control monkeys at different times and their components. Results (1) The effect of gallbladder was obvious. The gallbladder effect was significant in the high-dose group. The bile volume and bile acid content were significantly different from those in the blank control group (P<0.05), while the bile volume was lower in the low-dose group than in the control group. The difference was significant (P<0.05). (2) Cholesterol content and bilirubin content were significantly lower in the high-dose group than in the control group (P<0.05); Conclusion Dachaihu Decoction treatment must use large doses to increase bile secretion and bile acid content, reduce the synthesis of bilirubin and cholesterol, and ensure the efficacy of the drug.