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目的:探讨2型糖尿病患者胰岛素抵抗及脂代谢紊乱对下肢动脉粥样硬化的影响。方法:2型糖尿病患者62例分为观察组30例和对照组32例,观察组合并下肢动脉粥样硬化;对照组无下肢动脉病变,两组分别进行葡萄糖耐量试验和胰岛素释放试验,计算出胰岛素敏感指数,并测定血脂各指标。结果:观察组的甘油三酯、总胆固醇、LDL-C、HDL-C分别为2.8±1.2、5.9±0.9、3.9±0.8、0.8±0.3mmol/L,对照组相应为1.8±1.0、5.0±0.9、2.9±0.9、1.4±0.5mmol/L,观察组的胰岛素敏感指数为-5.8±0.6,对照组为-4.1±0.5,两组比较差异均有统计学意义(P<0.05～P<0.01)。结论:胰岛素抵抗、血脂代谢紊乱是2型糖尿病合并下肢动脉粥样硬化患者的危险因素,增加胰岛素敏感性和纠正脂代谢紊乱可有效地防止2型糖尿病患者动脉粥样硬化的发生和发展。
Objective: To investigate the effects of insulin resistance and dyslipidemia on atherosclerosis in lower extremities in type 2 diabetic patients. Methods: Sixty-two patients with type 2 diabetes mellitus were divided into observation group (n = 30) and control group (n = 32). The observation group had lower extremity arterial atherosclerosis. The control group had no lower extremity arterial disease. The two groups were subjected to glucose tolerance test and insulin release test Insulin sensitivity index, and the determination of lipid indicators. Results: The levels of triglyceride, total cholesterol, LDL-C and HDL-C in the observation group were 2.8 ± 1.2, 5.9 ± 0.9, 3.9 ± 0.8 and 0.8 ± 0.3 mmol / L respectively, while those in the control group were 1.8 ± 1.0 and 5.0 ± 0.9,2.9 ± 0.9,1.4 ± 0.5mmol / L, insulin sensitivity index of the observation group was -5.8 ± 0.6, the control group was -4.1 ± 0.5, the differences between the two groups were statistically significant (P <0.05 ~ P <0.01 ). Conclusion: Insulin resistance and dyslipidemia are risk factors for type 2 diabetes mellitus with atherosclerosis in lower extremities. Increasing insulin sensitivity and correcting dyslipidemia can effectively prevent the occurrence and development of atherosclerosis in type 2 diabetic patients.