[Objective] To optimize the extraction technology of effective components from DAPHNES CORTEX by orthogonal test. [Method] The effects of ethanol concentration, ethanol dosage, refluxing time and refluxing times on the extraction of daphnetin, total coumarins and total flavonoids were investigated by orthogonal test with multi-index comprehensive evaluation. Data processing was carried out with the multiple guidelines grading method. [Result] The optimal extraction technology of effective components was that DAPHNES CORTEX was refluxed twice with 70% ethanol at the solid-liquid ratio of 1∶ 8 (g/mL), 2 h each time. [Conclusion] Because of well-designed design, this technology could extract effective components from DAPHNES CORTEX with reliable results and satisfied effects. [Objective] To optimize the extraction technology of effective components from DAPHNES CORTEX by orthogonal test. [Method] The effects of ethanol concentration, ethanol dosage, refluxing time and refluxing times on the extraction of daphnetin, total coumarins and total flavonoids were investigated by orthogonal test with multi-index comprehensive evaluation. [Result] The optimal extraction technology of effective components was that DAPHNES CORTEX was refluxed twice with 70% ethanol at the solid-liquid ratio of 1: 8 (g / mL), 2 h each time. [Conclusion] Because of well-designed design, this technology could extract effective components from DAPHNES CORTEX with reliable results and satisfied effects.