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目的 研究了 [3H] 洛非西定的吸收和绝对生物利用度。方法 分二剂量组 ( 0 2mg·kg-1,0 0 5mg·kg-1) ,用统计矩法测定 po及iv给予大鼠 [3H] 洛非西定后的药物动力学参数 ,计算生物利用度。结果 高剂量组绝对生物利用度F为 5 4 0 % ;低剂量F为 5 4 7%。结论 口服给药后吸收较快 ,吸收率较高 ,药物吸收呈线性
OBJECTIVE To study the absorption and absolute bioavailability of [3H] lobesfamide. Methods Two-dose group (0 2 mg · kg-1, 0 5 mg · kg-1) was used to calculate the pharmacokinetic parameters of pooled and iv-administered [3H] degree. Results The absolute bioavailability F of high-dose group was 54.0% and low-dose F was 54.7%. Conclusion After oral administration, the absorption is faster, the absorption rate is higher, and the drug absorption is linear