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目的通过对南澳县中心小学一起腺病毒和流感病毒混合感染暴发疫情的流行病学分析,探索流行因素,为制定防控措施提供依据。方法采用描述性流行病学分析方法,对学校报告病例进行个案调查,入户调查部分流感样病例的家庭成员发病情况,调查县医院及县城个体诊所近期收治流感样病人情况,采集部分病人急性期与恢复期血清检测腺病毒和流感病毒抗体滴度。结果全校2周内共发生发热缺勤病例298例,罹患率为16.44%,其中符合流感样病例诊断标准23例,部分病例有家庭聚集性。采集病人咽拭子35份检测腺病毒和流感病毒,PCR检测结果腺病毒阳性12份,B型流感病毒阳性16份,其中2份腺病毒及B型流感病毒均阳性;采集5例病人双份血清,3例B型流感病毒抗体滴度呈4倍以上增长。结论初步认为该小学短期内出现腺病毒和流感病毒混合感染局部暴发,病原体考虑为腺病毒及B型流感病毒。
Objective To explore epidemiological analysis of an outbreak of the outbreak of the combined infection of adenovirus and influenza virus in Nan’ao County Central Primary School to explore epidemic factors and provide basis for prevention and control measures. Methods A descriptive epidemiological analysis method was used to carry out a case study on the reported cases of the school. The incidence of family members in some influenza-like cases was investigated in the households and the recent cases of influenza-like illness were investigated in the individual clinics of county hospitals and county clinics. Some patients were collected during the acute phase And convalescent sera were tested for adenovirus and influenza virus antibody titers. Results A total of 298 cases of absent fever were found within 2 weeks of the school. The attack rate was 16.44%, which met the diagnostic criteria of influenza-like cases in 23 cases. Some cases had familial aggregation. Thirty-five cases of throat swab were collected to test for adenovirus and influenza virus. PCR results showed that 12 were positive for adenovirus and 16 were positive for type B influenza virus, of which 2 were positive for adenovirus and type B influenza virus; Serum, 3 cases of influenza B virus antibody titers increased more than 4 times. Conclusion It is preliminarily thought that local outbreak of adenovirus and influenza virus mixed infection occurs in short time in this primary school. Pathogen is considered as adenovirus and influenza B virus.