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目的:探讨Ⅳ型胶原蛋白(COL4A2)基因多态性与女性骨密度的关系。方法:采用病例-对照研究方法,应用PCR-RFLP方法检测COL4A2基因型,采用Logistic回归法分析COL4A2基因多态性与骨密度间的关系。结果:绝经前后女性骨质疏松组及骨量流失组CC基因型及C等位基因频率均较正常对照组高(P<0.05);Logistic回归分析,COL4A2基因CC基因型与绝经前后女性骨量流失及骨质疏松有统计学相关性(OR=18.375,95%CI:5.189～65.065,P=0.000;OR=15.369,95%CI:3.224～73.269,P=0.001)。结论:COL4A2基因CC基因型是女性骨量流失和骨质疏松发病的独立危险因素。
Objective: To investigate the relationship between COL4A2 gene polymorphism and female bone mineral density. Methods: The genotypes of COL4A2 were detected by PCR-RFLP using case-control study. The relationship between COL4A2 gene polymorphism and bone mineral density was analyzed by Logistic regression. Results: The CC genotype and C allele frequency of osteoporosis group and osteoporosis group before and after menopause were higher than those of normal control group (P <0.05). Logistic regression analysis showed that CC genotype of COL4A2 gene correlated with bone mass Loss and osteoporosis were statistically significant (OR = 18.375, 95% CI: 5.189-65.065, P = 0.000; OR = 15.369, 95% CI: 3.224-73.269, P = 0.001). Conclusion: CC genotype of COL4A2 gene is an independent risk factor for the incidence of bone loss and osteoporosis in women.